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PhD Student (f/m/d) Pre-clinical development and validation of Adapter-RevCAR‐T-cell-system for immunotherapy of melanoma

With cutting-edge research in the fields of ENERGY, HEALTH and MATTER, around 1,500 employees from more than 70 nations at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) are committed to mastering the great challenges facing society today.

At the Institute of Radiopharmaceutical Cancer Research scientists (f/m/d) from the fields of physics, chemistry, biology, pharmacy, immunology, medicine and IT develop innovative radiopharmaceuticals and novel tools for functional characterization, improved imaging and personalized treatment of tumors.

The Department of Radioimmunology is looking for a PhD Student (f/m/d) Pre-clinical development and validation of Adapter-RevCAR‐T-cell-system for immunotherapy of melanoma.

Recruitment is subject to final approval by the project sponsor. In the 2nd year there is the option of increasing the weekly working hours to 75%.

Your tasks

• Generation and characterization of RevCAR-expressing human T-cells on a laboratory scale
• Design, generation and characterization of RevCAR targeting molecules (RevTMs) targeting different melanoma markers
• Testing the functionality and efficiency of novel RevTMs in combination with RevCAR-T-cells (RevCAR-T-cell-systems) for monospecific targeting of melanoma cells using 2D and 3D spheroid in vitro models and/or mouse models
• Generation of Dual-RevCAR-T-cells and their functional validation in combination with two different RevTMs (Dual-RevCAR-T-cell approach) for targeting of two melanoma markers (combinatorial melanoma targeting) using 2D and/or 3D spheroid in vitro models and/or mouse models

Your profile

• Completed university studies (Master/Diploma) in the field of Biology, Biotechnology, (Bio-) Chemistry or related field
• Solid knowledge of immunology, protein biochemistry and/or immunotherapy as well as good skills/experience in molecular biology, protein biochemistry, generation of recombinant proteins, working with cell cultures, flow cytometry and in vitro co-culture assays and willingness to work with experimental mice
• Be fascinated by scientific research and innovation, be motivated, enthusiastic and eager to learn, be able to work methodically and accurately, be able to work independently yet also being a team player, have a creative mind and strong problem-solving skills and have a good writing and oral expression
• Fluent written and spoken English skills

Our offer

• A vibrant research community in an open, diverse and international work environment
• Scientific excellence and extensive professional networking opportunities
• A structured PhD program with a comprehensive range of continuing education and networking opportunities - more information about the PhD program at the HZDR can be found here
• Salary and social benefits in accordance with the collective agreement for the public sector (TVöD-Bund) including 30 days of paid holiday leave, company pension scheme (VBL)
• We support a good work-life balance with the possibility of part-time employment, mobile working and flexible working hours
• Numerous company health management offerings
• Employee discounts with well-known providers via the platform Corporate Benefits
• An employer subsidy for the "Deutschland-Ticket Jobticket"

We look forward to receiving your application documents (including cover letter, CV, diplomas/transcripts, etc.), which you can submit via our online-application-system.